Factors Affecting Dissolution Rate of Cellulose Acetate Phthalate in Aqueous Solution
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چکیده
منابع مشابه
Factors Affecting Dissolution Rate
Solubility of drug plays a prime role in controlling its dissolution from dosage form. Aqueous solubility of drug is a major factor that determines its dissolution rate. Minimum aqueous solubility of 1% is required to avoid potential solubility limited absorption problems. Studies of 45 compound of different chemical classes and a wide range of solubilities revealed that initial dissolution rat...
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BACKGROUND Cellulose acetate phthalate (CAP) has been used for several decades in the pharmaceutical industry for enteric film coating of oral tablets and capsules. Micronized CAP, available commercially as "Aquateric" and containing additional ingredients required for micronization, used for tablet coating from water dispersions, was shown to adsorb and inactivate the human immunodeficiency vi...
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The heat of dissolution of cellulose in one imidazolium acetate ionic liquid was determined experimentally. The value of -132 ± 8 J g(-1) indicates that the dissolution is exothermal thus confirming energetically favourable cellulose-ionic liquid interactions but indicating that an increase in temperature does not thermodynamically favour the dissolution process.
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An experimental investigation is described on the surface electric characterization of a commercially available latex, Aquateric, composed of cellulose acetate phthalate polymer particles, and used in enteric-controlled drug release. Since the surface charge of dispersed systems is an essential parameter governing most of their behavior, it is of fundamental importance to characterize how that ...
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Gall-stone dissolution rate was measured in 52 patients with radiolucent gall stones in a functioning gall bladder receiving chenic acid 15 mg/kg/day. Percentage reduction in gall-stone area at six months was inversely related to initial gall-stone diameter (n = 52; r = -0.53; p less than 0.001), and to cholesterol saturation index of fasting gall-bladder bile during treatment (n = 28; r = -0.6...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1970
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.18.2350